The 4th Ergothioneine and Selenoneine Research Conference, hosted by Euglena Co., Ltd., was successfully conducted online on November 21, 2023. The event featured a special symposium and a series of presentations, highlighting the latest advancements in the study of ergothioneine and selenoneine, two antioxidants with potential health benefits.

Event Highlights:

1. Special Symposium by Professor Barry Halliwell:
   • Professor Halliwell's lecture, "Is Ergothioneine a Protective Factor Against Neurodegeneration and a Promoter of Healthy Ageing?" was a centerpiece of the event. He emphasized the potential role of ergothioneine in combating neurodegenerative diseases and promoting healthy aging. The discussion included insights into the biochemical pathways through which ergothioneine might exert its protective effects.
2. Invited Lecture on Tau Protein and Ergothioneine:
   • The lecture by Noritaka Nakamichi focused on the inhibitory effects of ergothioneine on tau protein phosphorylation. This is significant in the context of Alzheimer's disease, where abnormal tau phosphorylation is a key feature. They discussed the molecular mechanisms and potential therapeutic implications of their findings.
3. General Presentations:
   • A series of presentations covered diverse aspects of ergothioneine and selenoneine research:
     • Cognitive Enhancement and Biomarkers: This study explored how ergothioneine might improve cognitive functions and identified potential biomarkers for its activity.
     • Selenoneine Concentrates from Yellowfin Tuna: Researchers presented their work on extracting selenoneine from Yellowfin tuna blood meat, emphasizing the production methods and assessing food safety.
     • Inhibitory Effects on Melanin Production: This presentation focused on how selenoneine can suppress melanin production in fish, which has implications for understanding pigmentation processes.
     • Skin Quality Improvement with Ergothioneine-rich Mushrooms: An intriguing study that examined the impact of high ergothioneine-containing mushrooms on skin quality, combining animal and clinical trials.
     • Ergothioneine in Cosmetics: This talk discussed the potential use of fermented ergothioneine in cosmetic applications, a promising area for future product development.

The conference successfully facilitated the exchange of cutting-edge research and ideas among experts in the field. Participants included academics, industry professionals, and students, who engaged in discussions that spanned from basic research to practical applications in health and cosmetology. The event highlighted the growing interest in ergothioneine and selenoneine as compounds with significant potential for health benefits, particularly in the areas of aging, cognitive function, and skin health.